One of the benefits of participating in this study is receiving test results and biometrics using some of the most cutting edge technology available.* See more below!
RightEye
The FDA-cleared RightEye Vision System™ uses infered tracking technology to can measure thousands of parameters of eye movement.
BrainCheck
BrainCheck is a computerized cognitive assessment aid, a prescription Software as a Medical Device (SaMD) that uses an individual’s score(s) on a battery of cognitive tasks to provide an interpretation of their current level of cognitive function. Registered as a FDA Class II medical device (Registration number: 3014129043). BrainCheck is a diagnostic aid used by the clinician, not a stand-alone diagnostic.
WAVi
WAVi uses EEG technology to measure brainwave activity throughout different auditory and visual activities
View more about WAVi technology here!
What Tests and Why
| Name | Device / Method | Purpose & Data Captured | Optional / Required |
|---|---|---|---|
| RightEye | Computer-based infrared eye tracker | Measures dynamic eye movement patterns (e.g., saccades, pursuits) to assess neurological function. Abnormal patterns and metrics like Choice Reaction Time can be objective signs of neuroinflammation or cognitive dysfunction ("brain fog"). | Required |
| WAVi™ SCAN | EEG Headset | Measures brain electrical activity (electroencephalography) during cognitive tasks. Provides objective data on brain function, including processing speed, attention, and reaction time. Key metrics include Audio P300 Voltage and Central Parietal Average Voltage. | Required |
| NASA 10-Minute Lean Test | Manual vital signs & observation | A standardized provocative test to assess for autonomic dysfunction (e.g., POTS) by measuring changes in heart rate and blood pressure upon passive standing/leaning against a wall. | Optional |
| STAT Earpiece | In-ear sensor | Continuously and non-invasively measures blood flow and blood pressure throughout the visit, capturing real-time data on autonomic function and cerebral perfusion during various activities. | Optional |
| Capillaroscopy | Microscopic camera | Non-invasively images the capillaries in the nailbeds to assess microcirculation, vascular structure, and small vessel health, which can be affected by systemic inflammation and endothelial dysfunction. | Optional |
| Hypermobility & Physical Assessments | Clinical examination (e.g., Beighton score), vital signs, anthropometrics | Quantifies joint hypermobility, assesses general physical function, and includes spine assessment, vital signs, and measurements like height, weight, and waist circumference. | Required |
| Evie Ring | Smart finger wearable device | Provided to participants for continuous, longitudinal tracking of key health metrics (Heart Rate, HRV, SpO2, sleep, activity) in their real-world environment post-visit. | Optional (Data Sharing) |
| Blood | Venipuncture (up to 100 mL) | Multi-omics approach: immune profiling (FLIP), proteomics (Olink & Legendplex), metabolomics (Nightingale Health), glycomics (GlycanAge), steroidomics (Metabolomics Centre), epigenetics (TruDiagnostic), pathogen profiling (metagenomic analysis, ddPCR), and host genetics (Admera Health). | Required |
| Saliva (Salivette®) | Self-collection (Salivette®) | Frozen to capture microbes from the mouth attached to the antibodies that recognize them, providing a new window into host-microbe interactions. | Required |
| Saliva (OraSure®) | Self-collection (OraSure®) | Preserves DNA and protein for metagenomics (bacteria, fungi, parasites, viruses like EBV/CMV) and profiling of salivary proteins, including antibodies. Builds on prior research on salivary antibodies in COVID-19. | Required |
| Urine | Self-collection (Clean Catch) | Used for pathogen profiling, metabolomics (metabolic state), and kidney function markers. | Required |
| Sweat | Device-assisted (Macroduct Advanced) | Analyzes secreted molecules, including antimicrobial proteins like SCGB1D2, which may affect susceptibility to Lyme disease. | Optional |
| Throat Swab | Clinician-administered | Samples the oropharynx for mucosal immunity, pathogen presence (especially strep), and local microbiome composition. | Optional |
| Vaginal Swab (Liquid Preservative) | Self-collection | Preserves DNA for metagenomic analysis, pathogen detection, and inflammatory markers in the female reproductive tract. | Optional |
| Vaginal Swab (Dry) | Self-collection | Tests for antigens and intact microorganisms from the female reproductive tract. | Optional |
| Rectal Swab | Self-collection | Analyzes the gut microbiome, a key site of immune regulation often implicated in systemic inflammation. | Optional |
*Some test results and biometrics are available for release to participants in a research capacity and are not to be used for diagnostic purposes. Please discuss any personal medical or health concerns with your clinician.